- Anania Shirakatsi, medieval Armenian scholar
- George Gurdjieff, mystic and philosopher
- Sergey Merkurov, sculptor
- Sheram, gusan, poet and composer
- Avetik Isahakyan, poet
- Armen Tigranian, opera composer
- Olga Chekhova, actress
- Khachatur Avetisyan, composer
- Hovhannes Shiraz, poet
- Mher Mkrtchyan, actor
- Levon Ishtoyan, footballer, Soviet champion with FC Ararat (1973)
- Vazgen Manukyan, former Prime Minister of Armenia
- Svetlana Svetlichnaya, film actress
- Edmond Keosayan, film director
- Levon Mkrtchyan, film director
- Yurik Vardanian, weightlifting Olympic champion (1980)
- Robert Emmiyan, European long jump record holder
- Artur Petrosyan, footballer, all-time leading scorer for Armenia
- Levon Julfalakyan, wrestling Olympic champion (1988)
- Mnatsakan Iskandaryan, wrestling Olympic champion (1992)
- Gennady Timchenko, businessman
- Israel Militosyan, weightlifting Olympic champion (1992)
- Ashot Mkhitaryan, distinguished weightlifting trainer
- Mkrtich Armen, novelist
Other famous natives include singers Zaruhi Dolukhanyan, Shara Talyan, and Araksi Gyulzadyan.
Composers Nikoghayos and Armen Tigranyans.
Poets Avetik Isahakyan, Shushanik Kurghinyan, and Hovhannes Shiraz.
Actors and directors Mher Mkrtchyan, Albert Mkrtchyan, and Edmon Qyosayan.
Academicians Artashes Shahinyan, Sergey Hambardzumyan, Rafayel Aleksandryan, Christopher Koshtonyants, Aleksandr Hakobyan, Armenak Mnjoyan, Karlen Adamyan, and Ruben Zaryan.
Great Armenologists Ervand Lalayan and Grigor Khalatyan.
World famous sculptors Sergey Merkurov and Ferdinant Soghoyan. Most of the frescoes painted by Minas Avetisyan are located in Gyumri. Learn more here.